GLP-1 medications like Ozempic, Wegovy, and Mounjaro have become some of the most talked-about drugs in recent years. Originally approved by the FDA to treat Type 2 diabetes back in 2017, these injections weren’t designed for weight loss—but that hasn’t stopped millions from using them for exactly that purpose.
Medications such as Ozempic and Wegovy have been helping people to manage their weight (Michael Siluk/UCG/Universal Images Group via Getty Images)
In fact, according to KFF Health News, around 15.5 million U.S. adults—nearly 6% of the population—are now on a GLP-1 drug. With dramatic weight loss results, it’s easy to see the appeal. But alongside the positives, users are also reporting some surprising side effects that go way beyond nausea and stomach upset.
The “Ozempic Face” Effect
We’ve already heard about “Ozempic face”—the gaunt, hollowed-out look that can happen when weight drops rapidly. Now, some users are noticing even more specific changes: their eyes looking sunken.
One Reddit user shared their story, comparing themselves to reality TV star Scott Disick, who sparked headlines after appearing noticeably thinner last year. The user explained they’d lost around 15kg (33 pounds) in six months but were alarmed to see their eyes looking hollow and their face aging quickly.
It can cause the face to ‘hollow’ out (Getty Images)
While some dismissed the change as part of natural aging, others pointed out that facial fat loss is a common result of GLP-1 medications. According to Drugs.com, “Ozempic Face” often means:
- Hollow cheeks
- Sunken eyes
- Dark under-eye circles
- Wrinkles and sagging skin around the jawline
Basically, people can end up looking older than their actual age, which isn’t exactly the glow-up most were expecting.
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Why Does It Happen?
Doctors say it’s not just about fat loss—it’s also about how quickly the weight comes off. Dr. Patrick Byrne, president of the American Academy of Facial Plastic and Reconstructive Surgery, told The New York Post that GLP-1 medications often lead to faster and more dramatic changes than traditional dieting. Because the weight comes off so rapidly, the face can appear more hollow than it might from slower, gradual weight loss.
It’s also worth noting that this isn’t unique to Ozempic. Rapid weight loss from surgery, crash diets, or even fasting can cause similar changes in facial appearance.
What Should You Do If You Notice Changes?
Experts emphasize that anyone using GLP-1 medication should be under medical supervision. If you’re noticing unexpected side effects—whether it’s changes to your eyes, skin, or even your libido—it’s important to talk to your doctor.
It’s not just Ozempic that can alter the appearance of the face (Getty Images)
Novo Nordisk, the maker of Ozempic, has stated:
“Patient safety is of the utmost importance… we recommend patients take these medications for their approved indications and under the supervision of a healthcare professional.”
If you experience side effects, you can also report them through the MHRA Yellow Card Scheme.
Bottom Line
Ozempic and similar medications can be life-changing, but they also come with some very visible side effects. While weight loss might feel like a win, the impact on your face and eyes may surprise you. The key takeaway? Stay informed, work closely with your healthcare provider, and remember—slow and steady weight loss is usually kinder to both your health and your reflection in the mirror.
